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Urine typically contains epithelial cells shed from the urinary tract, and urine cytology evaluates this urinary sediment for the presence of cancerous cells [2] [3] from the lining of the urinary tract, and it is a convenient noninvasive technique for follow-up analysis of patients treated for urinary tract cancers.
Urothelial cell cancers comprise just over half of primary urethral cancers. Roughly another quarter of cases are squamous cell carcinomas, and the majority of the remainder are adenocarcinomas, which originate from the cells of various secretory glands in and around the urethra. Up to 10% of primary urethral cancers have variant histology ...
Common sites for squamous metaplasia include the bladder and cervix. Smokers often exhibit squamous metaplasia in the linings of their airways. These changes don't signify a specific disease, but rather usually represent the body's response to stress or irritation. Vitamin A deficiency or overdose can also lead to squamous metaplasia. [1]
The transitional epithelium cells stretch readily in order to accommodate fluctuation of volume of the liquid in an organ (the distal part of the urethra becomes non-keratinized stratified squamous epithelium in females; the part that lines the bottom of the tissue is called the basement membrane).
They must distinguish a benign metaplastic change from the cancerous condition urothelial cell carcinoma. [2] It is a very common finding in bladder biopsies and cystectomies, and most often found in the trigone area.
Transitional epithelial cells, also known as urothelial cells, line the urinary tract from the renal pelvis through the ureters and bladder and, in males, the upper portion of the urethra. They are smaller than squamous cells and their shape varies based on the layer of epithelium from which they are derived, but they are most commonly round or ...
Bladder tumors are classified by their appearance under the microscope, and by their cell type of origin. Over 90% of bladder tumors arise from the cells that form the bladder's inner lining, called urothelial cells or transitional cells; the tumor is then classified as urothelial cancer or transitional cell cancer.
Benign tumors of bone can be similar macroscopically and require a combination of a clinical history with cytogenetic, molecular, and radiologic tests for diagnosis. [23] Three common forms of benign bone tumors with are giant cell tumor of bone, osteochondroma, and enchondroma; other forms of benign bone tumors exist but may be less prevalent.