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Selective iron deposition in the beta cells of pancreatic islets leads to diabetes [4] [2] due to the distribution of transferrin receptor on the beta cells of islets [3] and in the skin leads to hyperpigmentation. Hemosiderin deposition in the brain is seen after bleeds from any source, including chronic subdural hemorrhage, cerebral ...
Hemosiderin image of a kidney viewed under a microscope. The brown areas represent hemosiderin. Hemosiderin or haemosiderin is an iron-storage complex that is composed of partially digested ferritin and lysosomes. The breakdown of heme gives rise to biliverdin and iron. [1] [2] The body then traps the released iron and stores it as hemosiderin ...
Hemosiderin hyperpigmentation is pigmentation due to deposits of hemosiderin, and occurs in purpura, haemochromatosis, hemorrhagic diseases, and stasis dermatitis. [ 1 ] : 853 See also
Iron deposition most commonly occurs in the liver, pancreas, skin, heart, and joints. People with iron overload classically present with the triad of liver cirrhosis, secondary diabetes mellitus, and bronze skin. [3] However, due to earlier detection nowadays, symptoms are often limited to general chronic malaise, arthralgia, and hepatomegaly. [3]
Targetoid hemosiderotic hemangioma, also known as a hobnail hemangioma is a skin condition characterized by a central brown or purplish papule that is surrounded by an ecchymotic halo. [1] [2] It may appear similar to melanoma. It was first described by Santa Cruz and Aronberg in 1988. [2]
A siderophage is a hemosiderin-containing macrophage. Heart failure cells are siderophages generated in the alveoli of the lungs of people with left heart failure or chronic pulmonary edema, when the high pulmonary blood pressure causes red blood cells to pass through the vascular wall. [1] Siderophages are not specific of heart failure.
The stain is an important histochemical stain used to demonstrate the distribution and amount of iron deposits in liver tissue, often in the form of a biopsy. [6] [7] Perls's procedure may be used to identify excess iron deposits such as hemosiderin deposits (hemosiderosis) and in conditions such as hereditary hemochromatosis. [8]
Schamberg's disease, (also known as "progressive pigmentary dermatosis of Schamberg", [1] "purpura pigmentosa progressiva" (PPP), [1] and "Schamberg's purpura" [1]) is a chronic discoloration of the skin found in people of all ages, usually only affecting the feet, legs or thighs or a combination.