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The overall incidence of adverse drug reactions to sulfa antibiotics is approximately 3%, close to penicillin; [3] hence medications containing sulfonamides are prescribed carefully. Sulfonamide drugs were the first broadly effective antibacterials to be used systemically, and paved the way for the antibiotic revolution in medicine.
Sulfanilamide (also spelled sulphanilamide) is a sulfonamide antibacterial drug. Chemically, it is an organic compound consisting of an aniline derivatized with a sulfonamide group. [1] Powdered sulfanilamide was used by the Allies in World War II to reduce infection rates and contributed to a dramatic reduction in mortality rates compared to ...
Sulfonamide-trimethoprim combinations (co-trimoxazole) are still used extensively against opportunistic infections in patients with AIDS, urinary infections and in the treatment of burns. However, in many other situations, sulfa drugs have been replaced by beta-lactam antibacterials.
Author of The Demon Under the Microscope, a history of the discovery of the sulfa drugs; A History of the Fight Against Tuberculosis in Canada (Chemotherapy) Presentation speech, Nobel Prize in Physiology and Medicine, 1939; The History of WW II Medicine "Five Medical Miracles of the Sulfa Drugs". Popular Science, June 1942, pp. 73–78.
Many important drugs contain the sulfonamide group. [1] A sulfonamide (compound) is a chemical compound that contains this group. The general formula is R−SO 2 NR'R" or R−S(=O) 2 −NR'R", where each R is some organic group; for example, "methanesulfonamide" (where R = methane, R' = R" = hydrogen) is CH 3 SO 2 NH 2.
If used during pregnancy, it may increase the risk of kernicterus in the baby. [1] While the company that makes it does not recommend use during breastfeeding, use is believed to be safe if the baby is otherwise healthy. [2] It is in the sulfonamide class of medications. [1] Sulfadiazine was approved for medical use in the United States in 1941.
Young adults are taking the supercommute into work, a trend that will only likely continue as return-to-office mandates from Amazon, JP Morgan, and others continue.. Molly Hopkins, age 30, has ...
It is a good antibacterial drug, but its water solubility is very pH dependent. Thus there is a risk of crystallization within the bladder or urethra , which could lead to pain or blockage. As with other sulfonamides, there is a significant risk of agranulocytosis , and this, rather than the development of resistance by bacteria, is the main ...
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