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Chromatin remodeling is the dynamic modification of chromatin architecture to allow access of condensed genomic DNA to the ... (for example) methylate or acetylate ...
In molecular biology, SWI/SNF (SWItch/Sucrose Non-Fermentable), [1] [2] is a subfamily of ATP-dependent chromatin remodeling complexes, which is found in eukaryotes.In other words, it is a group of proteins that associate to remodel the way DNA is packaged.
Specific CHD complexes, such as the nucleosome remodeling deacetylase complex in C. elegans, can expose binding sites for transcriptional repressors along the chromatin by interacting with highly-modular histone tails; deacetylation of the histone residue H3K9ac is an example of how the NuRD complex can downregulate gene expression and affect ...
The ability of histone acetyltransferases to manipulate chromatin structure and lay an epigenetic framework makes them essential in cell maintenance and survival. The process of chromatin remodeling involves several enzymes, including HATs, that assist in the reformation of nucleosomes and are required for DNA damage repair systems to function ...
For example, it was proposed that ... Chromatin Remodeling: Chromatin remodeling can result from covalent modification of histones that physically remodel, move or ...
ADPr is an important mechanism in gene regulation that affects chromatin organization, the binding of transcription factors, and mRNA processing through poly-ADP ribose polymerase (PARP) enzymes. There are multiple types of PARP proteins, but the subclass of DNA-dependent PARP proteins including PARP-1, PARP-2, and PARP-3 interact with the ...
RSC (Remodeling the Structure of Chromatin) is a member of the ATP-dependent chromatin remodeler family. The activity of the RSC complex allows for chromatin to be remodeled by altering the structure of the nucleosome. [1] There are four subfamilies of chromatin remodelers: SWI/SNF, INO80, ISW1, and CHD. [2]
Nucleosome Remodeling Factor (NURF) is an ATP-dependent chromatin remodeling complex first discovered in Drosophila melanogaster (fruit fly) that catalyzes nucleosome sliding in order to regulate gene transcription. It contains an ISWI ATPase, making it part of the ISWI family of chromatin remodeling complexes. NURF is highly conserved among ...