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A single 5 gram (5000 mg) oral dose in healthy adults results in a peak plasma creatine level of approximately 120 mg/L at 1–2 hours post-ingestion. Creatine has a fairly short elimination half life, averaging just less than 3 hours, so to maintain an elevated plasma level it would be necessary to take small oral doses every 3–6 hours ...
The risk of using Ephedra gave rise to creatine. [6] Creatine is a supplement that was used by a lot of athletes in the 1992 Olympics where it gained most of its popularity from. Creatine was considered a form of pre-workout in the late 1990s until the early 2000s where it was then later used with a mixture of other supplements. [7]
Patients with myoadenylate deaminase deficiency do not retain ribose during heavy exercise, so supplementation may be required to rebuild levels of ATP. [20] [21] Creatine monohydrate could also be helpful for AMPD patients, as it provides an alternative source of energy for anaerobic muscle tissue and was found to be helpful in the treatment ...
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