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The pars compacta (SNpc) is one of two subdivisions of the substantia nigra of the midbrain (the other being the pars reticulata); it is situated medial to the pars reticulata. It is formed by dopaminergic neurons. [1] It projects to the striatum and portions of the cerebral cortex. [2] It is functionally involved in fine motor control.
The most prominent function of the pars compacta is motor control, [17] though the substantia nigra's role in motor control is indirect; electrical stimulation of the substantia nigra does not result in movement, due to mediation of the striatum in the nigral influence of movement. The pars compacta sends excitatory input to the striatum via D1 ...
The substantia nigra is located in the ventral midbrain of each hemisphere. It has two distinct parts, the pars compacta (SNc) and the pars reticulata (SNr). The pars compacta contains dopaminergic neurons from the A9 cell group that forms the nigrostriatal pathway that, by supplying dopamine to the striatum, relays information to the basal ganglia.
executive functions; ADHD; addiction; schizophrenia; Nigrostriatal pathway: The nigrostriatal pathway transmits dopaminergic neurons from the zona compacta of the substantia nigra [8] to the caudate nucleus and putamen. The substantia nigra is located in the midbrain, while both the caudate nucleus and putamen are located in the dorsal striatum ...
The pedunculopontine nucleus lies below the red nucleus, caudal to the substantia nigra and adjacent to the superior cerebellar peduncle.It has two divisions of subnuclei; the pars compacta, containing mainly cholinergic neurons, and the pars dissipata, containing mainly glutamatergic neurons and some non-cholinergic neurons.
Substantia nigra. Pars compacta; Pars reticulata; Interpeduncular nucleus; Cerebral peduncle. Crus cerebri; Mesencephalic cranial nerve nuclei. Oculomotor nucleus (III) Edinger-Westphal nucleus; Trochlear nucleus (IV) Mesencephalic duct (cerebral aqueduct, aqueduct of Sylvius)
The midbrain tegmentum is also an important part of the dopaminergic system which is essential for feelings of reward and pleasure. Two regions in the midbrain tegmentum are of particular interest. The first one is the substantia nigra which is an important part of the nigrostriatal pathway. This pathway serves to coordinate motor movements and ...
Photomicrograph of neuromelanin (brown material) in a neuron of the substantia nigra. Hematoxylin and eosin stain. The scale bar is 20 microns (0.02mm) in length. Neuromelanin gives specific brain sections, such as the substantia nigra or the locus coeruleus, distinct color. It is a type of melanin and similar to other forms of peripheral melanin.