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Iron overload (also known as haemochromatosis or hemochromatosis) is the abnormal and increased accumulation of total iron in the body, leading to organ damage. [1] The primary mechanism of organ damage is oxidative stress, as elevated intracellular iron levels increase free radical formation via the Fenton reaction.
Intravenous iron infusions can cause skin rash, hives, itchiness and flush. Skin staining and discolouration can occur at the site of infusion if the iron and saline solution leaks outside the vein into the surrounding tissue. [14] Skin discolouration can be semi-permanent or permanent.
Positive histologic stains that aid in the diagnosis of conditions of or affecting the human integumentary system Stain Cell, material, and/or structure(s) stained Condition(s) in which stain is positive Actin-specific enolase: Infantile digital fibromatosis: AE1/AE3: Squamous cell carcinoma: Alcian blue: Lipoid proteinosis Papular mucinosis ...
H&E stain. Prussian blue iron staining, highlighting the hemosiderin pigment as blue. This finding indicates mesenchymal iron overload (within Kupffer cells and/or portal macrophages) rather than parenchymal iron overload (within hepatocytes). [7] There are several methods available for diagnosing and monitoring hemosiderosis including: Serum ...
The staining reactions of the mucin are variable. Alcian blue has occasionally produced false negative results; however, colloidal iron staining has been shown to be superior. [17] [18] Direct immunofluorescence has demonstrated the accumulation of immunoglobulins, specifically IgM, along the basal layer in multiple instances.
Immunohistochemistry can be performed on tissue that has been fixed and embedded in paraffin, but also cryopreservated (frozen) tissue.Based on the way the tissue is preserved, there are different steps to prepare the tissue for immunohistochemistry, but the general method includes proper fixation, antigen retrieval incubation with primary antibody, then incubation with secondary antibody.
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Erythema ab igne (Latin for 'redness from fire') EAI, also known as hot water bottle rash, [2] is a skin condition caused by long-term exposure to heat (infrared radiation). [3] Prolonged thermal radiation exposure to the skin can lead to the development of reticulated erythema, hyperpigmentation, scaling, and telangiectasias in the