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Long term use may result in increased growth of fungi. [6] Use during pregnancy and breastfeeding appears to be safe. [6] Mupirocin is chemically a carboxylic acid. [8] It works by blocking a bacteria's ability to make protein, which usually results in bacterial death. [6] Mupirocin was initially isolated in 1971 from Pseudomonas fluorescens. [9]
However, widespread use of mupirocin is associated with development of mupirocin-resistant strains of MRSA, with one hospital in Canada experiencing an increase from 2.7% to 65% resistant strains in three years. [78]
Mupirocin: Bactroban: Ointment for impetigo, ... Similar structure with tetracycline, but five times stronger, big volume distribution and long half-time in the body
By culturing P. fluorescens, mupirocin (an antibiotic) can be produced, which has been found to be useful in treating skin, ear, and eye disorders. [23] Mupirocin free acid and its salts and esters are agents currently used in creams, ointments, and sprays as a treatment of methicillin-resistant Staphylococcus aureus infection.
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Topical antibiotics used may be a triple antibiotic ointment, bacitracin, or mupirocin. In patients failing topical treatment or more severe cases, oral antibiotics are an option; dicloxacillin or cephalexin can be used.
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