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A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn 2+) which stabilizes the fold. The term zinc finger was originally coined to describe the finger-like appearance of a hypothesized structure from the African clawed frog (Xenopus laevis) transcription factor IIIA.
This gene on the X chromosome is structurally similar to a related gene on the Y chromosome ().It encodes a member of the krüppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers.
Zinc finger protein 91 homolog is a protein that in humans is encoded by the ZFP91 gene. [5] [6] The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2 type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins.
The human gene maps to chromosome 2 q32.1 and consists of 4 exons that code for a protein of 1210 amino acids (137 kDa). [6] Little is known about the characteristics and function of the encoded protein. However, the protein sequence codes for a domain characteristic of a classical C 2 H 2-type zinc finger near the N-terminal end. [6] [7]
Zinc finger protein 331 is a protein that in humans is encoded by the ZNF331 gene. [3] Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in ...
Zinc finger Y-chromosomal protein is a protein that in humans is encoded by the ZFY gene of the Y chromosome. [3] [4] This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF. [4]
In molecular biology the ZZ-type zinc finger domain is a type of protein domain that was named because of its ability to bind two zinc ions. [1] These domains contain 4-6 Cys residues that participate in zinc binding (plus additional Ser/His residues), including a Cys-X2-Cys motif found in other zinc finger domains.
n/a Ensembl ENSG00000181896 n/a UniProt Q8IZC7 n/a RefSeq (mRNA) NM_001300949 NM_033204 n/a RefSeq (protein) NP_001287878 NP_149981 n/a Location (UCSC) Chr 19: 19.67 – 19.68 Mb n/a PubMed search n/a Wikidata View/Edit Human Zinc finger protein 101 is a protein that in humans is encoded by the ZNF101 gene. Function Zinc finger proteins (ZNFs), such as ZNF101, bind nucleic acids and perform ...