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In molecular biology, protein aggregation is a phenomenon in which intrinsically-disordered or mis-folded proteins aggregate (i.e., accumulate and clump together) either intra- or extracellularly. [1] [2] Protein aggregates have been implicated in a wide variety of diseases known as amyloidoses, including ALS, Alzheimer's, Parkinson's and prion ...
There is a distinction between aggregate data and individual data. Aggregate data refers to individual data that are averaged by geographic area, by year, by service agency, or by other means. [2] Individual data are disaggregated individual results and are used to conduct analyses for estimation of subgroup differences. [2]
The evolution of biological complexity is one important outcome of the process of evolution. [1] Evolution has produced some remarkably complex organisms – although the actual level of complexity is very hard to define or measure accurately in biology, with properties such as gene content, the number of cell types or morphology all proposed as possible metrics.
The product itself depends on the purpose of the model, but one of the most common examples is the study of total biomass. A notable example of the success of FBA is the ability to accurately predict the growth rate of the prokaryote E. coli when cultured in different conditions. [10]
Fixation rates can easily be modeled as well to see how long it takes for a gene to become fixed with varying population sizes and generations. For example, The Biology Project Genetic Drift Simulation allows to model genetic drift and see how quickly the gene for worm color goes to fixation in terms of generations for different population sizes.
Thus, common evolutionary rates could be forcing the genes for certain proteins to evolve together while preventing other genes from being co-opted unless there is a shift in evolutionary rate. [2] Constructional selection: When a gene exists in many duplicated copies, it may be maintained because of the many connections it has (also termed ...
With the arrival of evolutionary developmental biology in the late 20th century, heterotopy has been identified in changes in growth rate; in the distribution of proteins in the embryo; the creation of the vertebrate jaw; the repositioning of the mouth of nematode worms, and of the anus of irregular sea urchins. Heterotopy can create new ...
Another example is plant self-incompatibility alleles. When two plants share the same incompatibility allele, they are unable to mate. Thus, a plant with a new (and therefore, rare) allele has more success at mating, and its allele spreads quickly through the population. [9] A similar example is the csd alleles of the honey bee. A larva that is ...