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Lumateperone was approved for medical use in the United States in December 2019 with an initial indication for schizophrenia, [4] [5] and became available in February 2020. [2] It has since demonstrated efficacy in bipolar depression and received FDA approval in December 2021 for depressive episodes associated with both bipolar I and II disorders.
Quetiapine and the combination of olanzapine and fluoxetine have both demonstrated effectiveness in bipolar depression. [21] In light of recent evidence, olanzapine (Zyprexa) has been FDA approved as an effective monotherapy for the maintenance of bipolar disorder. [22]
In 1970, lithium was approved by the United States Food and Drug Administration (FDA) for the treatment of bipolar disorder, which remains its primary use in the US. [ 5 ] [ 17 ] It is sometimes used when other treatments are not effective in a number of other conditions, including major depression , [ 18 ] schizophrenia , disorders of impulse ...
The FDA hasn’t approved ketamine to treat bipolar disorder. However, it’s been used off-label to manage pain and depression since the 1970s and may have antidepressant and anti-suicidal ...
Amisulpride (Solian) – approved in low doses as a monotherapy for persistent depression and major depressive disorder [10] Levosulpiride – approved in low doses for major depressive disorder [11] Lumateperone (Caplyta) – approved as a monotherapy for bipolar depression; Lurasidone (Latuda) – approved as a monotherapy for bipolar depression
In 2013, it was approved in Canada and by the U.S. Food and Drug Administration (FDA) to treat bipolar depression, either as monotherapy or adjunctively with lithium or valproate. [ 15 ] [ 16 ] It has no effect on manic symptoms and is more potent for treating major depressive disorder or depressive episodes associated with bipolar disorder.
The U.S. Food and Drug Administration expanded approval for Johnson & Johnson’s nasal spray, Spravato, to allow it to be used as a standalone treatment for patients with severe depression, the ...
In the United States, the Food and Drug Administration (FDA) has approved quetiapine for the treatment of schizophrenia and of acute manic episodes associated with bipolar disorder (bipolar mania) and for treatment of bipolar depression. [97] In 2009, quetiapine XR was approved as adjunctive treatment of major depressive disorder. [98]
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