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Pulmonary capillary hemangiomatosis (PCH) is a disease affecting the blood vessels of the lungs, where abnormal capillary proliferation and venous fibrous intimal thickening result in progressive increase in vascular resistance. [1] It is a rare cause of pulmonary hypertension, and occurs predominantly in young adults.
An increase in Pi causes extraalveolar blood vessels to reduce in caliber, in turn causing blood flow to decrease (extraalveolar blood vessels are those blood vessels outside alveoli). Intraalveolar blood vessels (pulmonary capillaries) are thin walled vessels adjacent to alveoli which are subject to the pressure changes described by zones 1-3.
Major aortopulmonary collateral arteries (MAPCAs) develop early in embryonic life but regress as the normal pulmonary arteries (vessels that will supply deoxygenated blood to the lungs) develop. [2] In certain heart conditions the pulmonary arteries do not develop. The collaterals continue to grow, and can become the main supply of blood to the ...
De-oxygenated blood leaves the heart, goes to the lungs, and then enters back into the heart. [2] De-oxygenated blood leaves through the right ventricle through the pulmonary artery. [2] From the right atrium, the blood is pumped through the tricuspid valve (or right atrioventricular valve) into the right ventricle.
The pulmonary artery carries deoxygenated blood from the right ventricle to the lungs. [11] The blood here passes through capillaries adjacent to alveoli and becomes oxygenated as part of the process of respiration. [12] In contrast to the pulmonary arteries, the bronchial arteries supply nutrition to the lungs themselves. [10]: 790
Perfusion may also refer to fixation via perfusion, used in histological studies. Perfusion is measured as the rate at which blood is delivered to tissue, [2] or volume of blood per unit time (blood flow) per unit tissue mass. The SI unit is m 3 /(s·kg) [citation needed], although for human organs perfusion is typically reported in ml/min/g. [3]
Blood resistance varies depending on blood viscosity and its plugged flow (or sheath flow since they are complementary across the vessel section) size as well, and on the size of the vessels. Assuming steady, laminar flow in the vessel, the blood vessels behavior is similar to that of a pipe.
The bronchial arteries and their supply of nutrients to the lungs are also attributed to the observation that an occluded (either ligated or by an embolus) pulmonal artery very rarely results in lung infarction. [9] The bronchial arteries can maintain a supply of oxygenated blood to lung tissue.