Search results
Results from the WOW.Com Content Network
p3 peptide generates from the 17-40 or 17-42 sequence of the amyloid precursor protein , which is a type I integral membrane protein concerned in neurons’ synapses in many human tissues. Under normal physiological conditions, APP is processed with three different proteolytic enzymes: α-, β-and γ-secretases. At first, APP molecule is cut by ...
Amyloid beta (Aβ, Abeta or beta-amyloid) denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. [2] The peptides derive from the amyloid-beta precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ in a cholesterol ...
Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. It functions as a cell surface receptor [ 5 ] and has been implicated as a regulator of synapse formation , [ 6 ] neural plasticity , [ 7 ] antimicrobial activity, [ 8 ] and iron export . [ 9 ]
The most well-known substrate of gamma secretase is amyloid precursor protein, a large integral membrane protein that, when cleaved by both gamma and beta secretase, produces a short 37-43 [verification needed] amino acid peptide called amyloid beta whose abnormally folded fibrillar form is the primary component of amyloid plaques found in the ...
The ordinary generating function of a sequence can be expressed as a rational function (the ratio of two finite-degree polynomials) if and only if the sequence is a linear recursive sequence with constant coefficients; this generalizes the examples above. Conversely, every sequence generated by a fraction of polynomials satisfies a linear ...
sequence - Overall generic and amyloidogenic regions based on the consensus PASTA 2.0 [30] 2014 Web Server - PASTA 2.0: Secondary structure-related. Predicts the most aggregation-prone portions and the corresponding β-strand inter-molecular pairing for multiple input sequences. sequence top pairings and energies, mutations and protein-protein
In a polynomial code over () with code length and generator polynomial () of degree , there will be exactly code words. Indeed, by definition, p ( x ) {\displaystyle p(x)} is a code word if and only if it is of the form p ( x ) = g ( x ) ⋅ q ( x ) {\displaystyle p(x)=g(x)\cdot q(x)} , where q ( x ) {\displaystyle q(x)} (the quotient ) is of ...
The binary Golay code, G 23 is a perfect code. That is, the spheres of radius three around code words form a partition of the vector space. G 23 is a 12-dimensional subspace of the space F 23 2. The automorphism group of the perfect binary Golay code G 23 (meaning the subgroup of the group S 23 of permutations of the coordinates of F 23