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Phenylbiguanide (PBG) is a 5-HT3 agonist used to study the role of 5-HT3 receptors in the central nervous system. [1] It has been found to trigger dopamine release in the nucleus accumbens of rats. [ 2 ]
Biguanide (/ b aɪ ˈ ɡ w ɒ n aɪ d /) is the organic compound with the formula HN(C(NH)NH 2) 2. It is a colorless solid that dissolves in water to give a highly basic solution. It is a colorless solid that dissolves in water to give a highly basic solution.
[2] [5] DOHx has shown the highest affinity for the serotonin 5-HT 2A and 5-HT 2C receptors of any other assessed DOx drug in multiple studies. [2] [3] [6] [5] In one study, its affinities for the human serotonin 5-HT 2 receptors were 0.1 nM for the 5-HT 2A receptor, 30 nM for the 5-HT 2B receptor, and 0.7 nM for 5-HT 2C receptor.
[1] [2] [7] For comparison, the affinities of LSD and DOM in the same study were 6.31 nM and 18.6 nM, respectively. [7] DOSB substitutes for LSD in rodent drug discrimination tests, albeit much less potently than DOM ( ED 50 Tooltip median effective dose = 1.80 mg/kg versus 0.148 mg/kg, respectively; ~12-fold difference) and with only partial ...
The affinity (IC 50 Tooltip half-maximal inhibitory concentration) of VU0530244 for the serotonin 5-HT 2B receptor was found to be 17.3 nM. [3] Its affinity (IC 50) values at the serotonin 5-HT 2A and 5-HT 2C receptors were greater than 10,000 nM (>578-fold less than for the serotonin 5-HT 2B receptor). [3]
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2,5-Dimethoxy-4-cyanoamphetamine (DOCN) is a serotonergic drug of the phenethylamine, amphetamine, and DOx families. [1] [2] [3] It is a DOx derivative with a cyano group (–C≡N) at the 4 position of the molecule. [1] [2] [3] The drug shows much lower affinities for the serotonin 5-HT 2 receptors than other DOx drugs.
En toutes lettres (2009-2011) Et 1, et 2, et 3 ! (1999) Face à ... Informations and programs at programmes.france2.fr [in French ... List of programs broadcast by ...