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The final part of the small intestine is the ileum, which leads into the large intestine. The ileum leads to the ileum cecum valve, which is the beginning of the large intestine. The large intestine, also known as the large bowel, is the last part of the gastrointestinal (GI) tract and of the digestive system.
The colon (progressing from the ascending colon to the transverse, the descending and finally the sigmoid colon) is the longest portion of the large intestine, and the terms "large intestine" and "colon" are often used interchangeably, but most sources define the large intestine as the combination of the cecum, colon, rectum, and anal canal.
The intestine is also called the bowel or the gut. The lower GI starts at the pyloric sphincter of the stomach and finishes at the anus. The small intestine is subdivided into the duodenum, the jejunum and the ileum. The cecum marks the division between the small and large intestine. The large intestine includes the rectum and anal canal. [2]
The lower gastrointestinal tract includes most of the small intestine and all of the large intestine. [15] In human anatomy , the intestine ( bowel or gut ; Greek: éntera ) is the segment of the gastrointestinal tract extending from the pyloric sphincter of the stomach to the anus and as in other mammals, consists of two segments: the small ...
The intestinal epithelium is the single cell layer that forms the luminal surface (lining) of both the small and large intestine (colon) of the gastrointestinal tract. Composed of simple columnar epithelium its main functions are absorption, and secretion. Useful substances are absorbed into the body, and the entry of harmful substances is ...
In the large intestines, villi are absent and a flat surface with thousands of glands is observed. Underlying the epithelium is the lamina propria, which contains myofibroblasts, blood vessels, nerves, and several different immune cells, and the muscularis mucosa which is a layer of smooth muscle that aids in the action of continued peristalsis ...
The gastroileal reflex is stimulated by the presence of food in the stomach and gastric peristalsis. Initiation of the reflex causes peristalsis in the ileum and the opening of the ileocecal valve (which allows the emptying of the ileal contents into the large intestine, or colon). [1]
Polysaccharidases and disaccharidases in the glycocalyx break down large sugar molecules, which are then absorbed. Glucose crosses the apical membrane of the enterocyte using the sodium-glucose cotransporter. It moves through the cytosol (cytoplasm) and exits the enterocyte via the basolateral membrane (into the blood capillary) using GLUT2.