Ad
related to: pten phosphatase
Search results
Results from the WOW.Com Content Network
Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. [6] Mutations of this gene are a step in the development of many cancers , specifically glioblastoma, lung cancer, breast cancer, and prostate cancer.
PTEN also refers to a member of the class, phosphatase and tensin homolog. [ citation needed ] This enzyme participates in 10 metabolic pathways : inositol phosphate metabolism , phosphatidylinositol signaling system , p53 signaling pathway , focal adhesion , tight junction , endometrial cancer , glioma , prostate cancer , melanoma , and small ...
[14] [page needed] Germline mutations in PTEN (phosphatase and tensin homolog), a tumor suppressor gene, are found in up to 80% of Cowden's patients. [10] Several other hereditary cancer syndromes, such as Bannayan–Riley–Ruvalcaba syndrome, have been associated with mutations in the PTEN gene as well.
In biochemistry, a phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol. Because a phosphatase enzyme catalyzes the hydrolysis of its substrate , it is a subcategory of hydrolases . [ 1 ]
PtdIns(3,4,5)P 3 is dephosphorylated by the phosphatase PTEN on the 3 position, generating PI(4,5)P 2, and by SHIPs (SH2-containing inositol phosphatase) on the 5' position of the inositol ring, producing PI(3,4)P 2. [5] The PH domain in a number of proteins binds to PtdIns(3,4,5)P 3. Such proteins include Akt/PKB, [6] PDPK1, [7] Btk1, and ARNO ...
Loss of PTEN function leads to over-activation of Akt and is common in cancer cells (PTEN is a tumour suppressor). SH2-containing Inositol Phosphatase (SHIP) also dephosphorylates PI(3,4,5)P 3, at the 5' position of the inositol ring. [22] The PI3K-Akt pathway regulates PTEN levels by affecting its transcription and activity.
In triple-negative breast cancer (TNBC), oncogenic activation of the PI3K/AKT/mTOR pathway can happen as a function of overexpression of upstream regulators like EGFR, activating mutations of PIK3CA, loss of function or expression of phosphatase and tensin homolog (PTEN), and the proline-rich inositol polyphosphatase, which are downregulators ...
RhoA-GTP stimulates the phospholipid phosphatase activity of PTEN (phosphatase and tensin homologue), a human tumor suppressor protein. This stimulation seems to depend on ROCK. [8] [9] In this way, PTEN is important to prevent uncontrolled cell division as is exhibited in cancer cells.
Ad
related to: pten phosphatase