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Traditionally the amount of HDL-C is used as a proxy to measure the amount of HDL particles, and from there a proxy for the reverse cholesterol transport capacity. However, a number of conditions that increase reverse cholesterol transport (e.g. being male) will reduce HDL-C due to the greater clearance of HDL, making such a test unreliable.
Hypercholesterolemia, also called high cholesterol, is the presence of high levels of cholesterol in the blood. [1] It is a form of hyperlipidemia (high levels of lipids in the blood), hyperlipoproteinemia (high levels of lipoproteins in the blood), and dyslipidemia (any abnormalities of lipid and lipoprotein levels in the blood).
High-density lipoprotein (HDL) is one of the five major groups of lipoproteins. [1] Lipoproteins are complex particles composed of multiple proteins which transport all fat molecules around the body within the water outside cells.