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The angle of His forms an anatomical sphincter. This prevents the reflux of stomach acid, digestive enzymes, and duodenal bile from entering the esophagus. [4] [5] This is important in preventing gastroesophageal reflux disease and inflammation of the esophagus. [5]
In gastroenterology, esophageal pH monitoring is the current gold standard for diagnosis of gastroesophageal reflux disease (GERD). It provides direct physiologic measurement of acid in the esophagus and is the most objective method to document reflux disease, assess the severity of the disease and monitor the response of the disease to medical or surgical treatment.
Infants and children who have had unpleasant eating experiences (e.g. acid reflux or food intolerance) may be reluctant to eat their meals. [66] Additionally, force feeding an infant or child can discourage proper self-feeding practices and in-turn cause undue stress on both the child and their parents. [66]
Acid reflux into the mouth can cause breakdown of the enamel, especially on the inside surface of the teeth. A dry mouth, acid or burning sensation in the mouth, bad breath and redness of the palate may occur. [27] Less common symptoms of GERD include difficulty in swallowing, water brash, chronic cough, hoarse voice, nausea and vomiting. [26]
There are several classes of drugs for acid-related disorders, such as dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD), or laryngopharyngeal reflux. The World Health Organization gives drugs in these classes the categorization code ATC code A02.
In medicine, pink lady is a term used for a combination of medications used to treat gastroesophageal reflux or gastritis. It usually consists of an antacid and the anaesthetic lidocaine. Some variants contain an anticholinergic. The name of the preparation comes from its colour – pink.
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Normally, histamine acts on H 2 to stimulate acid secretion; drugs that inhibit H 2 signaling thus reduce the secretion of gastric acid. H 2-antihistamines are among first-line therapy to treat gastrointestinal conditions including peptic ulcers and gastroesophageal reflux disease. Some formulations are available over the counter.
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