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  2. Pharmacodynamics of spironolactone - Wikipedia

    en.wikipedia.org/wiki/Pharmacodynamics_of...

    Spironolactone has been identified as an inhibitor of NRG1‐ERBB4 signaling. [142] Spironolactone has been found to act as a potent inhibitor of the pannexin 1 channel, and this action appears to be involved in its antihypertensive effects independently of MR antagonism. [143] Spironolactone has been found to block hERG channels. [144]

  3. Spironolactone - Wikipedia

    en.wikipedia.org/wiki/Spironolactone

    Spironolactone can cause hyperkalemia, or high blood potassium levels. [111] Rarely, this can be fatal. [111] Of people with heart disease prescribed typical dosages of spironolactone, 10 to 15% develop some degree of hyperkalemia, and 6% develop severe hyperkalemia. [111] At a higher dosage, a rate of hyperkalemia of 24% has been observed. [119]

  4. Peripheral edema - Wikipedia

    en.wikipedia.org/wiki/Peripheral_edema

    The condition is commonly associated with vascular and cardiac changes associated with aging but can be caused by many other conditions, including congestive heart failure, kidney failure, liver cirrhosis, portal hypertension, trauma, alcoholism, altitude sickness, pregnancy, hypertension, sickle cell anemia, a compromised lymphatic system or merely long periods of time sitting or standing ...

  5. Could Spironolactone Help Women With Hair Thinning, Facial ...

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  6. Chronic venous insufficiency - Wikipedia

    en.wikipedia.org/wiki/Chronic_venous_insufficiency

    Chronic venous insufficiency (CVI) is a medical condition characterized by blood pooling in the veins, leading to increased pressure and strain on the vein walls. [1] The most common cause of CVI is superficial venous reflux, which often results in the formation of varicose veins, a treatable condition. [2]

  7. Podiatrists Say These Compression Socks Can Help Reduce Leg ...

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    The best compression socks for women relieve leg swelling and pain by boosting circulation. Check out these picks based on expert advice and editor testing. Podiatrists Say These Compression Socks ...

  8. Mineralocorticoid receptor antagonist - Wikipedia

    en.wikipedia.org/wiki/Mineralocorticoid_receptor...

    Eplerenone is a newer drug that was developed as a spironolactone analog with reduced adverse effects. In addition to the y-lactone ring and the substituent on C-7, eplerenone has a 9α,11α-epoxy group. This group is believed to be the reason why eplerenone has a 20-40-fold lower affinity for the mineralocorticoid receptor than spironolactone. [7]

  9. Does Low Estrogen Cause Hair Loss? - AOL

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    Being underweight or very overweight could cause lower estrogen levels. ... may have fewer side effects than other treatments like spironolactone. They’re also available over the counter, so ...

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