Search results
Results from the WOW.Com Content Network
14719 Ensembl ENSG00000125166 ENSMUSG00000031672 UniProt P00505 P05202 RefSeq (mRNA) NM_002080 NM_001286220 NM_010325 RefSeq (protein) NP_001273149 NP_002071 NP_034455 Location (UCSC) Chr 16: 58.71 – 58.73 Mb Chr 8: 96.59 – 96.62 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Aspartate aminotransferase, mitochondrial is an enzyme that in humans is encoded by the GOT2 gene ...
Each subunit is composed of a large and a small domain, as well as a third domain consisting of the N-terminal residues 3-14; these few residues form a strand, which links and stabilizes the two subunits of the dimer. The large domain, which includes residues 48-325, binds the PLP cofactor via an aldimine linkage to the ε-amino group of Lys258.
The Global Offset Table, or GOT, is a section of a computer program's (executables and shared libraries) memory used to enable computer program code compiled as an ELF file to run correctly, independent of the memory address where the program's code or data is loaded at runtime.
The developed molecule GRK2ct is a protein inhibitor which inhibits the signalling properties of G βγ subunit but does not interfere with alpha subunit signalling. [25] The over expression of GRK2ct has been shown to significantly rescue cardiac function in murine models of heart failure by blocking G βγ subunit signalling. [ 26 ]
The GTP form of the α subunit of transducin (G t) activates the cyclic GMP phosphodiesterase from retinal rod outer segments, [3] and the GTP form of the α subunit of the stimulatory G protein (G s) activates hormone-sensitive adenylate cyclase. [4] [5] More than one type of G protein co-exist in the same tissue. For example, in adipose ...
When someone steals your Social Security number or Individual Taxpayer Identification Number, it can be used to file a fraudulent tax return. However, an Identity Protection PIN (IP PIN) from the ...
The OAT protein functions as a dimer and each monomer consists of a large domain, which contributes most to subunit interface, and a C-terminal small domain, and an N-terminal region containing a helix, loop, and three-stranded beta-meander. In the central large domain is a seven-stranded beta-sheet covered by eight helices.
The activated receptor promotes the exchange of bound GDP for GTP on the G protein alpha subunit. GTP binding changes the conformation of switch regions within the alpha subunit, which allows the bound trimeric G protein (inactive) to be released from the receptor, and to dissociate into active alpha subunit (GTP-bound) and beta/gamma dimer.