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Clofazimine is a phenazine dye and is believed to work by interfering with DNA. [1] Clofazimine was discovered in the 1950s at Trinity College, Dublin, [6] and approved for medical use in the United States in 1986. [1] It is on the World Health Organization's List of Essential Medicines. [7]
This is a major advantage of clofazimine over other antileprosy drugs. Ulcerative lesions caused by Mycobacterium ulcerans respond well to clofazimine. It also has some activity against M. tuberculosis and can be used as last resort therapy for the treatment of MDR tuberculosis. The most disturbing adverse reaction to clofazimine is a red-brown ...
This chronotype prefers to go to bed at around 11 p.m., according to the Sleep Foundation report. Bears account for around 55% of individuals. Wolf chronotypes are similar to "night owls."
The K v 1.3 blocker clofazimine has been reported to be effective in the treatment of chronic graft-versus-host disease, [60] cutaneous lupus, [61] [62] and pustular psoriasis [63] [64] in humans. Furthermore, clofazimine in combination with the antibiotics clarithromycin and rifabutin induced remission for about 2 years in patients with Crohn ...
They are not metabolized by the body but are excreted by the kidneys. Dwell time in the body varies greatly by species. Rodents have half-lives of days, while in humans they remain for years. Many animals show sex differences in the ability to rid the body of PFAAs, but without a clear pattern. Gender differences of half lives vary by animal ...
The U.S. Food and Drug Administration (FDA) on Thursday approved a new type of prescription pain medication for adults to treat moderate to severe acute pain. The drug, called Journavx ...
The Food and Drug Administration (FDA) recently approved the nasal spray Spravato for the treatment of major depression in people who have not responded to at least two oral antidepressants.
In vertebrates, the master circadian clock is contained within the suprachiasmatic nucleus (SCN), a bilateral nerve cluster of about 20,000 neurons. [10] [11] The SCN itself is located in the hypothalamus, a small region of the brain situated directly above the optic chiasm, where it receives input from specialized photosensitive ganglion cells in the retina via the retinohypothalamic tract.