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A chancre (/ ˈ ʃ æ ŋ k ər / SHANG-kər) [1] is a painless genital ulcer most commonly formed during the primary stage of syphilis. [2] This infectious lesion forms around 21 days after the initial exposure to Treponema pallidum, the gram-negative spirochaete bacterium causing syphilis, but can range from 10 to 90 days. [2]
Primary syphilis is typically acquired by direct sexual contact with the infectious lesions of another person. [19] Approximately 2–6 weeks after contact (with a range of 10–90 days) a skin lesion, called a chancre , appears at the site and this contains infectious bacteria.
Both lesions typically appear on the genitals of infected individuals; Both lesions can be present at multiple sites and with multiple lesions; Differences. Chancre is a lesion typical of infection with the bacterium that causes syphilis, Treponema pallidum; Chancroid is a lesion typical of infection with the bacterium Haemophilus ducreyi
Syphilis may be transmitted from mother to the fetus during any stage of pregnancy. [18] It is most commonly transmitted via cross placental transfer of Treponema pallidum bacteria from mother to the fetus during pregnancy with transmission via exposure to genital lesions during childbirth being less common. [18]
Condylomata lata occurs in about one-third of secondary syphilis patients and is characterized by painless, mucosal, and warty erosions which are flat, velvety, moist and broad base in nature. They tend to develop in warm, moist sites of the genitals and perineum. These lesions hold a high accumulation of spirochetes and are highly infectious.
Genital herpes ulcers. A genital ulcer is an open sore located on the genital area, which includes the vulva, penis, perianal region, or anus. Genital ulcers are most commonly caused by infectious agents (fungal infections, secondary bacterial infections, or sexually transmitted infections such as genital herpes, syphilis or chancroid).
Syphilis, in contrast, generally was transmitted by venereal sores holding a massive inoculation of Treponema pallidum. Previously uninfected adults, often elites who had been protected by their more hygienic lifestyles, therefore became much sicker upon infection, and died more often.
In syphilis, the gumma is caused by a reaction to spirochaete bacteria in the tissue. It appears to be the human body's way to slow down the action of this bacteria; it is a unique immune response that develops in humans after the immune system fails to kill off syphilis. [citation needed]
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