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Chiral drugs. Chemical compounds that come as mirror-image pairs are referred to by chemists as chiral or handed molecules. [1] Each twin is called an enantiomer. Drugs that exhibit handedness are referred to as chiral drugs. Chiral drugs that are equimolar (1:1) mixture of enantiomers are called racemic drugs and these are obviously devoid of ...
An enantiopure drug is a pharmaceutical that is available in one specific enantiomeric form. Most biological molecules (proteins, sugars, etc.) are present in only one of many chiral forms, so different enantiomers of a chiral drug molecule bind differently (or not at all) to target receptors. Chirality can be observed when the geometric ...
Omeprazole, sold under the brand names Prilosec and Losec, among others, is a medication used in the treatment of gastroesophageal reflux disease (GERD), peptic ulcer disease, and Zollinger–Ellison syndrome. [ 1 ] It is also used to prevent upper gastrointestinal bleeding in people who are at high risk. [ 1 ]
Contents. Eudysmic ratio. The eudysmic ratio (also spelled eudismic ratio) represents the difference in pharmacologic activity between the two enantiomers of a drug. In most cases where a chiral compound is biologically active, one enantiomer is more active than the other. The eudysmic ratio is the ratio of activity between the two.
Methamphetamine (METH) is a potent amphetamine-type stimulant that has high abuse potential and can be smoked, snorted, injected, or taken orally. The drug is high in lipid solubility and can cross the blood-brain barrier more readily than amphetamine due to the addition of an extra methyl group.
A chiral switch is a chiral drug that has already approved as racemate but has been re-developed as a single enantiomer. [ 1 ][ 2 ] The term chiral switching was introduced by Agranat and Caner in 1999 [ 3 ] to describe the development of single enantiomers from racemate drugs. For example, levofloxacin is a chiral switch of racemic ofloxacin.
Amphetamine[ note 2 ] (contracted from a lpha - m ethyl ph en et hyl amine) is a central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity. Amphetamine was discovered as a chemical in 1887 by Lazăr Edeleanu, and then as a drug in the late 1920s. [ 25 ]
Chiral molecules in the receptors in our noses can tell the difference between these things. Chirality affects biochemical reactions, and the way a drug works depends on what kind of enantiomer it is. Many drugs are chiral and it is important that the shape of the drug matches the shape of the cell receptor it is meant to affect.