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Abdominal pain, bone pain, confusion, depression, weakness [1] [2] Complications: Kidney stones, abnormal heart rhythm, cardiac arrest [1] [2] Causes: Primary hyperparathyroidism, cancer, sarcoidosis, tuberculosis, Paget disease, multiple endocrine neoplasia, vitamin D toxicity [1] [3] Diagnostic method
Vitamin D is a group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, along with numerous other biological functions. [ 1 ][ 2 ] In humans, the most significant compounds within this group are vitamin D 3 (cholecalciferol) and vitamin D 2 (ergocalciferol). [ 2 ][ 3 ]
Calcitriol is a hormone and the active form of vitamin D, normally made in the kidney. [ 8 ][ 9 ][ 10 ] It is also known as 1,25-dihydroxycholecalciferol. It binds to and activates the vitamin D receptor in the nucleus of the cell, which then increases the expression of many genes. [ 11 ]
Signs of vitamin D deficiency. Fatigue. Mood changes. Muscle pain and weakness. Reduced immune function. Increased inflammation. Frequent infections. Rickets (in children)
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by a group of symptoms that commonly include abdominal pain, abdominal bloating and changes in the consistency of bowel movements. [1] These symptoms may occur over a long time, sometimes for years. [2] IBS can negatively affect quality of life and may result ...
Vitamin D deficiency is typically diagnosed by measuring the concentration of the 25-hydroxyvitamin D in the blood, which is the most accurate measure of stores of vitamin D in the body. [1][7][2] One nanogram per millilitre (1 ng/mL) is equivalent to 2.5 nanomoles per litre (2.5 nmol/L). Severe deficiency: <12 ng/mL = <30 nmol/L[2] Deficiency ...
Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine, with Crohn's disease and ulcerative colitis (UC) being the principal types. [3] Crohn's disease affects the small intestine and large intestine, as well as the mouth, esophagus, stomach and the anus, whereas UC primarily affects the colon ...
Coeliac disease (British English) or celiac disease (American English) is a long-term autoimmune disorder, primarily affecting the small intestine, where individuals develop intolerance to gluten, present in foods such as wheat, rye and barley. [ 10 ] Classic symptoms include gastrointestinal problems such as chronic diarrhoea, abdominal ...
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