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Longitudinal tan, black, or brown streak on a nail; Pigmentation of proximal nail fold; Areas of dark pigmentation (palms of hands) Warning signs are new areas of pigmentation, or existing pigmentation that shows change. If caught early, acral lentiginous melanoma has a similar cure rate as the other types of superficial spreading melanoma. [12]
Melanonychia is a black or brown pigmentation of a nail, and may be present as a normal finding on many digits in Afro-Caribbeans, as a result of trauma, systemic disease, or medications, or as a postinflammatory event from such localized events as lichen planus or fixed drug eruption.
Oral pigmentation is asymptomatic and does not usually cause any alteration to the texture or thickness of the affected area. The colour can be uniform or speckled and can appear solitary or as multiple lesions. [1] Depending on the site, depth, and quantity of pigment, the appearance can vary considerably.
Melanocytes are melanin -producing neural crest -derived [3] cells located in the bottom layer (the stratum basale) of the skin's epidermis, the middle layer of the eye (the uvea), [4] the inner ear, [5] vaginal epithelium, [6] meninges, [7] bones, [8] and heart found in many mammals and birds. [9] Melanin is a dark pigment primarily ...
Blaschko's lines, also called the lines of Blaschko, are lines of normal cell development in the skin. These lines are only visible in those with a mosaic [1][2][3] skin condition or in chimeras where different cell lines contain different genes. These lines may express different amounts of melanin, [4] or become visible due to a differing ...
Melanocytic oral lesions are an extremely uncommon condition characterized by pigmented lesions of the mucous membranes. [1]: 807 ...
Melanocytic nevus. A melanocytic nevus (also known as nevocytic nevus, nevus-cell nevus and commonly as a mole) [1][2] is usually a noncancerous condition of pigment-producing skin cells. It is a type of melanocytic tumor that contains nevus cells. [2] A mole can be either subdermal (under the skin) or a pigmented growth on the skin, formed ...
The proximal zone, which is defined by deep epithelial invaginations occupied by overlaying ungual protrusions, is situated beneath the posterior nail fold. The distal zone, corresponding to the lunula , is made up of epithelial digitations that grow from the matrix epithelium and puncture the nail plate.