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Aspirin-exacerbated respiratory disease (AERD), also called NSAID-exacerbated respiratory disease (N-ERD) or historically aspirin-induced asthma and Samter's Triad, is a long-term disease defined by three simultaneous symptoms: asthma, chronic rhinosinusitis with nasal polyps, and intolerance of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs).
Salicylate intolerance is a form of food intolerance or of drug intolerance. Salicylate sensitivity is a pharmacological reaction, not a true IgE -mediated allergy. However, it is possible for aspirin to trigger non-allergic hypersensitivity reactions. [8][9] About 5–10% of asthmatics have aspirin hypersensitivity, but dietary salicylates ...
Anaphylaxis. Anaphylaxis (Greek: ana- 'up' + phylaxis 'guarding') is a serious, potentially fatal allergic reaction and medical emergency that is rapid in onset and requires immediate medical attention regardless of the use of emergency medication on site. [4][5] It typically causes more than one of the following: an itchy rash, throat closing ...
Hypersensitivity reactions are idiosyncratic reactions to a drug. [1] Although the term NSAID was introduced to signal a comparatively low risk of adverse effects, [2] NSAIDs do evoke a broad range of hypersensitivity syndromes. These syndromes have recently been classified by the European Academy of Allergy and Clinical Immunology Task Force ...
3–5% (lifetime prevalence) [4] Generalized anxiety disorder (GAD) is a mental and behavioral disorder, [5] specifically an anxiety disorder characterized by excessive, uncontrollable and often irrational worry about events or activities. [6] Worry often interferes with daily functioning, and individuals with GAD are often overly concerned ...
Pseudoallergy, sometimes known as nonallergic hypersensitivity, is a type of hypersensitivity reaction mostly described in the context of drug allergy. The mechanism is somewhat similar to the type 1 hypersensitivity in the Gell and Coombs classification in that the effector cell is also mast cell. In pseudoallergic reaction, the mast cell is ...
Salicylate poisoning. A skeletal structural formula for aspirin. Salicylate poisoning, also known as aspirin poisoning, is the acute or chronic poisoning with a salicylate such as aspirin. [1] The classic symptoms are ringing in the ears, nausea, abdominal pain, and a fast breathing rate. [1]
Acute severe asthma. Silent chest, worsening symptoms despite use of medication. [1] Acute severe asthma, also known as status asthmaticus, is an acute exacerbation of asthma that does not respond to standard treatments of bronchodilators (inhalers) and corticosteroids. [2] Asthma is caused by multiple genes, some having protective effect, with ...