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With IPG-DET the surgeon can place immediately dental implants by using autologous CGF [5] [6] growth factors, occasionally bone grafts materials as well as autologous stem cells or umbilical cord blood mesenchymal stem cells, in the same session, to increase the bone height in the sinus. [7] [8]
Stem-cell therapy uses stem cells to treat or prevent a disease or condition. [1] As of 2024, the only FDA-approved therapy using stem cells is hematopoietic stem cell transplantation. [2] [3] This usually takes the form of a bone marrow or peripheral blood stem cell transplantation, but the cells can also be derived from umbilical cord blood.
Any such potential beyond blood and immunological uses is limited by the fact that cord cells are hematopoietic stem cells (which can differentiate only into blood cells), and not pluripotent stem cells (such as embryonic stem cells, which can differentiate into any type of tissue). Cord blood has been studied as a treatment for diabetes. [55]
Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood, in order to replicate inside a patient and produce additional normal blood cells.
Cord blood is composed of all the elements found in whole blood – red blood cells, white blood cells, plasma, platelets. [6] Compared to whole blood some differences in the blood composition exist, for example, cord blood contains higher numbers of natural killer cells, lower absolute number of T-cells and a higher proportion of immature T-cells. [7]
The use of postnatal autologous stem cells, especially the mesenchymal stem cells is optimal in regenerative endodontic applications. These mesenchymal stem cells are found in dental pulp [ 20 ] [ 21 ] (DPSCs), the apical papilla [ 22 ] [ 23 ] (SCAP) and even in the inflamed periapical tissue [ 24 ] (iPAPCs) collected during endodontic surgical ...
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The e-PTFE membrane behaves as a barrier to prevent fibroblasts and various connective-tissue cells from entering the bone defect in order to allow the slower moving cells that are osteogenic to repopulate the defect. [15] A study used e-PTFE membranes to cover surgically constructed average size bone defects in the mandibular angles of rats.
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