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IPG-DET is a similar surgical procedure to maxillary sinus floor augmentation, but with three differences: the intentional perforation of the sinus membrane; the use of a purely autologus biomaterial [13] the entire procedure (insertion of the biomaterial, the bone graftand the dental implant) is performed in a single-stage surgery.
Stem-cell therapy uses stem cells to treat or prevent a disease or condition. [1] As of 2024, the only FDA-approved therapy using stem cells is hematopoietic stem cell transplantation. [2] [3] This usually takes the form of a bone marrow or peripheral blood stem cell transplantation, but the cells can also be derived from umbilical cord blood.
Any such potential beyond blood and immunological uses is limited by the fact that cord cells are hematopoietic stem cells (which can differentiate only into blood cells), and not pluripotent stem cells (such as embryonic stem cells, which can differentiate into any type of tissue). Cord blood has been studied as a treatment for diabetes. [55]
The e-PTFE membrane behaves as a barrier to prevent fibroblasts and various connective-tissue cells from entering the bone defect in order to allow the slower moving cells that are osteogenic to repopulate the defect. [15] A study used e-PTFE membranes to cover surgically constructed average size bone defects in the mandibular angles of rats.
The patient's own stored stem cells are then transfused into his/her bloodstream, where they replace destroyed tissue and resume the patient's normal blood-cell production. [2] Autologous transplants have the advantage of lower risk of infection during the immune-compromised portion of the treatment, since the recovery of immune function is rapid.
The use of postnatal autologous stem cells, especially the mesenchymal stem cells is optimal in regenerative endodontic applications. These mesenchymal stem cells are found in dental pulp [ 20 ] [ 21 ] (DPSCs), the apical papilla [ 22 ] [ 23 ] (SCAP) and even in the inflamed periapical tissue [ 24 ] (iPAPCs) collected during endodontic surgical ...
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Cord blood is composed of all the elements found in whole blood – red blood cells, white blood cells, plasma, platelets. [6] Compared to whole blood some differences in the blood composition exist, for example, cord blood contains higher numbers of natural killer cells, lower absolute number of T-cells and a higher proportion of immature T-cells. [7]
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