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Pramipexole, sold under the brand Mirapex among others, is a medication used to treat Parkinson's disease (PD) and restless legs syndrome (RLS). [8] In Parkinson's disease it may be used alone or together with levodopa. [8] It is taken by mouth. [8] Pramipexole is a dopamine agonist of the non-ergoline class. [8]
A dopamine agonist is a compound that activates dopamine receptors. ... Non-ergoline agonists include pramipexole, ropinirole, rotigotine, piribedil and apomorphine. [1]
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS) and are implicated in many neurological processes, including motivational and incentive salience, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling.
13490 Ensembl ENSG00000151577 ENSMUSG00000022705 UniProt P35462 P30728 RefSeq (mRNA) NM_000796 NM_001282563 NM_001290809 NM_033658 NM_033659 NM_033660 NM_033663 NM_007877 RefSeq (protein) NP_000787 NP_001269492 NP_001277738 NP_387512 NP_031903 Location (UCSC) Chr 3: 114.13 – 114.2 Mb Chr 16: 43.57 – 43.64 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Dopamine receptor D 3 is a ...
Medications used to treat RLS include dopamine agonists like pramipexole and gabapentinoids (α 2 δ ligands) like gabapentin. [ 4 ] [ 7 ] [ 16 ] RLS affects an estimated 2.5–15% of the American population. [ 4 ]
Dyskinesias with dopamine agonists are rare in younger patients, but along other side effects, more common in older patients. [9] All this has led to agonists being the preferential initial treatment for the former as opposed to levodopa in the latter. [9] Agonists at higher doses have also been related to a wide variety of impulse-control ...
Rapidly decreasing the use of levodopa or other dopamine agonists, such as pramipexole, may also trigger the condition. [1] [8] The underlying mechanism involves blockage of dopamine receptors. [1] Diagnosis is based on symptoms. [2] Management includes stopping the triggering medication, rapid cooling, and starting other medications. [2]
Dopamine D 2-like receptor agonists, including pramipexole, ropinirole, rotigotine, piribedil, bromocriptine, cabergoline, pergolide, and lisuride, have also been used to treat disorders of diminished motivation in humans.
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