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A/H5N1 virus can also infect mammals (including humans) that have been exposed to infected birds; in these cases, symptoms are frequently severe or fatal. All subtypes of the influenza A virus share the same genetic structure and are potentially able to exchange genetic material by means of reassortment [2] [3]
Influenza A virus subtype H5N1 (A/H5N1) is a subtype of the influenza A virus, which causes the disease avian influenza (often referred to as "bird flu"). It is enzootic (maintained in the population) in many bird populations, and also panzootic (affecting animals of many species over a wide area). [ 1 ]
Structure of influenza, showing neuraminidase marked as NA and hemagglutinin as HA. A highly pathogenic avian influenza A virus, A( H5N1 ), is known to infect humans as well as its original avian hosts , albeit quite infrequently. [ 11 ]
Forms the capsid, which coats the viral nucleoproteins and supports the structure of the viral envelope. M1 also assists with the function of the NEP protein. M2 (Matrix Protein 2) Forms a proton channel in the viral envelope, which is activated once a virion has bound to a host cell. This uncoats the virus, exposing its infective contents to ...
The hemagglutinin (H) and neuraminidase (N) proteins are key targets for antibodies and antiviral drugs, [10] [11] and they are used to classify the different serotypes of influenza A viruses, hence the H and N in H5N1. The genome sequence has terminal repeated sequences; repeated at both ends. Terminal repeats at the 5′-end 12–13 ...
The USDA’s Animal and Plant Health Inspection Service, which is maintaining the resources about the outbreak, released 239 genetic sequences of H5N1 samples taken from chickens, dairy cattle, a ...
H5N1 bird flu has been discovered in a pig in Oregon, a development that has sparked new concerns among infectious disease experts.
structure summary: The M1 protein is a ... It also has multiple regulatory functions, performed by interaction with the components of the host cell. ... H5N1 genetic ...