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Metoprolol was synthesized and its activity discovered in 1969. [12] The specific agent in on-market formulations of metoprolol is either metoprolol tartrate or metoprolol succinate, where tartrate is an immediate-release formulation and the succinate is an extended-release formulation (with 100 mg metoprolol tartrate corresponding to 95 mg ...
Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release [ER, XR, XL] dosage) or to a specific target in the body (targeted-release dosage).
[14] [15] [16] Bisoprolol, carvedilol, and sustained-release metoprolol are specifically indicated as adjuncts to standard ACE inhibitor and diuretic therapy in congestive heart failure, although at doses typically much lower than those indicated for other conditions. Beta blockers are only indicated in cases of compensated, stable congestive ...
Metoprolol; Nebivolol; β 2-selective agents Butaxamine (weak α-adrenergic agonist activity) - No common clinical applications, but used in experiments. ICI-118,551 Highly selective β 2-adrenergic receptor antagonist - No known clinical applications, but used in experiments due to its strong receptor specificity.
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The article lumps together metoprolol tartrate with succinate. The general pharmokinetics are similar, but not exactly the same. A distinction should be made. --Tarcieri 19:59, 5 February 2006 (UTC) It currently says that Toprol XL is "metoprolol succinate, the sustained release formulation".
"The Use of Medicines in the United States".IMS Institute for Healthcare Informatics.The Use of Medicines in the United States. June 2012. p. 40.
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