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21809 Ensembl ENSG00000119699 ENSMUSG00000021253 UniProt P10600 P17125 RefSeq (mRNA) NM_003239 NM_001329938 NM_001329939 NM_009368 RefSeq (protein) NP_001316867 NP_001316868 NP_003230 n/a Location (UCSC) Chr 14: 75.96 – 75.98 Mb Chr 12: 86.1 – 86.13 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transforming growth factor beta-3 is a protein that in humans is encoded by the ...
Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three [1] different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other signaling proteins.
Transforming growth factor-beta (TGF-beta) [6] is a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. TGF-beta-1 is a peptide of 112 amino acid residues derived by proteolytic cleavage from the C-terminal of a precursor protein.
Transforming growth factor beta (TGF-β) is a potent cell regulatory polypeptide homodimer of 25kD. [1] It is a multifunctional signaling molecule with more than 40 related family members. TGF-β plays a role in a wide array of cellular processes including early embryonic development, cell growth, differentiation, motility, and apoptosis. [2]
These are upregulated in Marfan's syndrome [1] [2] and some human cancers, and play crucial roles in tissue regeneration, cell differentiation, embryonic development, and regulation of the immune system. [3] [4] Isoforms of transforming growth factor-beta (TGF-β1) are also thought to be involved in the pathogenesis of pre-eclampsia. [5]
Findings suggest that T h 3 cells are a different lineage from naturally arising CD25 + CD4 + T reg cells, but it is still unclear whether T h 3 cells are the same as induced T reg cells because of the lack of a specific marker for T h 3 cells. It was previously shown that TGF-β was produced by intestinal dendritic cells, [5] [6] which has ...
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The protective and non-pathogenic T h 17 cells induced by IL-6 and TGF-β are termed as T reg 17 cells. The pathogenic T h 17 cells are induced by IL-23 and IL-1β. [5] IL-21, produced by T h 17 cells themselves, has also been shown to initiate an alternative route for the activation of T h 17 populations. [6]
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