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Cyproheptadine, sold under the brand name Periactin among others, is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. It was patented in 1959 and came into medical use in 1961. [ 5 ]
After chronic dosing of cyproheptadine (a rather high dose of 8-12mg for 5 days... typical doses are 2-4mg), it reduced growth hormone by over 50%. —Preceding unsigned comment added by 204.111.160.135 20:03, 28 April 2009 (UTC) I have added the reference and data to the adverse effects section of the article.
Some preliminary research suggested that citicoline may reduce the rates of death and disability following an ischemic stroke. [6] [7] However, the largest citicoline clinical trial to date (a randomised, placebo-controlled, sequential trial of 2,298 patients with moderate-to-severe acute ischaemic stroke in Europe), found no benefit of administering citicoline on survival or recovery from ...
Promethazine and other first generation antihistamines with a tricyclic structure were discovered in the 1940s.; Chlorpromazine, derived from promethazine originally as a sedative, was found to have neuroleptic properties in the early 1950s, and was the first typical antipsychotic.
All three of these agents, pizotifen, cyproheptadine, and clozapine act as non-selective monoamine receptor antagonists. [10] Pizotifen also fully blocks the effects of serotonergic psychedelics , including LSD , mescaline , 5-MeO-DMT , and DOM , in drug discrimination tests.
The following other wikis use this file: Usage on ar.wikipedia.org سيبروهيبتادين; Usage on azb.wikipedia.org سیپروهپتادین
Clemastine is an antihistamine with anticholinergic and sedative effects. Antihistamines competitively bind to histamine receptor sites, thus reducing the neurotransmitter's effects. [9]
Cyfeilliog (died c. 927) was a bishop in south-east Wales.The location and extent of his diocese is uncertain, but lands granted to him are mainly close to Caerwent, suggesting that his diocese covered Gwent, possibly extending into Ergyng (now south-west Herefordshire).