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Asparaginase is an enzyme that is used as a medication and in food manufacturing. [6] [7] As a medication, L-asparaginase is used to treat acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL). [6] It is given by injection into a vein, or muscle. [6] A pegylated version is also available. [8] In food manufacturing it is used to ...
Pegaspargase is a modified version of the enzyme asparaginase which has undergone PEGylation. [8] [6] It works by breaking down the amino acid asparagine that are circulating in the bloodstream. [6] The circulating asparagine is essential for the cancer cells to enable growth since they can't produce their own, in contrast to normal cells. [9]
Polyethylene glycol. PEGylation (or pegylation) is the process of both covalent and non-covalent attachment or amalgamation of polyethylene glycol (PEG, in pharmacy called macrogol) polymer chains to molecules and macrostructures, such as a drug, therapeutic protein or vesicle, which is then described as PEGylated.
4. Not Enough Vitamin D. You shouldn’t get too much sun, but some vitamin D exposure is essential.A review of studies found that people with certain autoimmune diseases may have a vitamin D ...
Calaspargase pegol is an engineered protein consisting of the E. coli-derived enzyme L-asparaginase II conjugated with succinimidyl carbonate monomethoxypolyethylene glycol . [6] The L-asparaginase portion hydrolyzes L-asparagine to L-aspartic acid depriving the tumor cell of the L-asparagine it needs for survival. [ 6 ]
Hydroxychloroquine has been linked to serious side effects, including cardiac arrest, heart rhythm issues, as well as liver failure and kidney disorders. FDA issued a warning for its use to treat ...
Health officials in Europe are investigating Ozempic and the trendy drug’s possible link to an eye-rotting condition that causes blindness. On Dec. 17, the European Medicines Agency announced ...
Side effects are common. [6] They may include headache, feeling tired, depression, trouble sleeping, hair loss, nausea, pain at the site of injection, and fever. [3] Severe side effects may include psychosis, autoimmune disorders, blood clots, or infections. [3] Use with ribavirin is not recommended during pregnancy. [3]