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As the name suggests, a non-nucleophilic base is a sterically hindered organic base that is a poor nucleophile.Normal bases are also nucleophiles, but often chemists seek the proton-removing ability of a base without any other functions.
In a similar implementation, 2,6-lutidine is thus sometimes used in organic synthesis as a sterically hindered mild base. [4] One of the most common uses for 2,6-lutidine is as a non-nucleophilic base in organic synthesis. It takes part in the formation of silyl ethers as shown in multiple studies. [5] [6]
Tetramethylguanidine is mainly used as a strong, non-nucleophilic base for alkylations, often as a substitute for the more expensive DBU and DBN. [3] Since it is highly water-soluble, it is easily removed from mixtures in organic solvents. It is also used as a base-catalyst in the production of polyurethane. [4]
2-tert-Butyl-1,1,3,3-tetramethylguanidine is an organic base, also known as Barton's base. It is named after Nobel Prize-winning British chemist Derek Barton . Barton and his assistants prepared a series of guanidines with steric hindrance in 1982; in this case five alkyl groups : four methyl groups and one tert -butyl group .
Pages in category "Non-nucleophilic bases" The following 26 pages are in this category, out of 26 total. This list may not reflect recent changes. ...
N,N-Diisopropylethylamine, or Hünig's base, is an organic compound that is a tertiary amine. It is named after the German chemist Siegfried Hünig . It is used in organic chemistry as a non-nucleophilic base. It is commonly abbreviated as DIPEA, DIEA, or i-Pr 2 NEt.
Typically, dementia is associated with classic symptoms like confusion and memory loss. But new research finds that there could be a less obvious risk factor out there: your cholesterol levels ...
It is used as a non-nucleophilic base, ... Structure. Like many lithium reagents it has a tendency to aggregate, forming a tetramer in the solid state. [2]