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  2. MEK inhibitor - Wikipedia

    en.wikipedia.org/wiki/MEK_inhibitor

    A MEK inhibitor is a chemical or drug that inhibits the mitogen-activated protein kinase kinase enzymes MEK1 and/or MEK2. They can be used to affect the MAPK/ERK pathway which is often overactive in some cancers.

  3. List of veterinary drugs - Wikipedia

    en.wikipedia.org/wiki/List_of_veterinary_drugs

    bedinvetmab - nerve growth factor inhibitor monoclonal antibody used for osteoarthritis in dogs; benazepril – ACE-inhibitor used in heart failure, hypertension, chronic kidney failure and protein-losing nephropathy; bethanechol – stimulates bladder contractions, tranquilizer, makes the patient feel no pain; bexagliflozin - oral antidiabetic ...

  4. p38 mitogen-activated protein kinases - Wikipedia

    en.wikipedia.org/wiki/P38_mitogen-activated...

    Oxidative stress is the most powerfully specific stress activating p38 MAPK. [7] Abnormal activity (higher or lower than physiological) of p38 has been implicated in pathological stresses in several tissues, that include neuronal, [8] [9] [10] bone, [11] lung, [12] cardiac and skeletal muscle, [13] [14] red blood cells, [15] and fetal tissues. [16]

  5. Mitogen-activated protein kinase - Wikipedia

    en.wikipedia.org/wiki/Mitogen-activated_protein...

    Despite the high number of MAPK genes, MAPK pathways of higher plants were studied less than animal or fungal ones. Although their signaling appears very complex, the MPK3, MPK4 and MPK6 kinases of Arabidopsis thaliana are key mediators of responses to osmotic shock , oxidative stress , response to cold and involved in anti-pathogen responses.

  6. Mitogen-activated protein kinase kinase - Wikipedia

    en.wikipedia.org/wiki/Mitogen-activated_protein...

    Mitogen-activated protein kinase kinase (also known as MAP2K, MEK, MAPKK) is a dual-specificity kinase enzyme which phosphorylates mitogen-activated protein kinase (MAPK). MAP2K is classified as EC 2.7.12.2. There are seven genes: MAP2K1 (a.k.a. MEK1) MAP2K2 (a.k.a. MEK2) MAP2K3 (a.k.a. MKK3) MAP2K4 (a.k.a. MKK4) MAP2K5 (a.k.a. MKK5) MAP2K6 (a ...

  7. Ilunocitinib - Wikipedia

    en.wikipedia.org/wiki/Ilunocitinib

    Ilunocitinib, sold under the brand name Zenrelia, is a veterinary medication used for the treatment of pruritus (itching) in dogs. [1] [3] It is a non-selective janus kinase inhibitor. [3] Ilunocitinib was approved for medical use in the United States in September 2024, [4] and in Canada in December 2024. [1]

  8. Selumetinib - Wikipedia

    en.wikipedia.org/wiki/Selumetinib

    Selumetinib is a kinase inhibitor, more specifically a selective inhibitor of the enzyme mitogen-activated protein kinase kinase (MAPK kinase or MEK) subtypes 1 and 2. These enzymes are part of the MAPK/ERK pathway, which regulates cell proliferation (i.e., growth and division) and is overly active in many types of cancer. [18]

  9. MAP kinase kinase kinase - Wikipedia

    en.wikipedia.org/wiki/MAP_kinase_kinase_kinase

    Mitogen Activated Protein (MAP) kinase kinase kinase (MAPKKK, [1] MKKK, [2] M3K, [3] or, MAP3K [4]) is a serine/threonine-specific protein kinase which acts upon MAP kinase kinase. Subsequently, MAP kinase kinase activates MAP kinase. Several types of MAPKKK can exist but are mainly characterized by the MAP kinases they activate.