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Influenza A virus and influenza B virus circulate in humans and cause seasonal epidemics, and influenza C virus causes a mild infection, primarily in children. Influenza D virus can infect humans but is not known to cause illness. In humans, influenza viruses are primarily transmitted through respiratory droplets from
Structure of influenza, showing neuraminidase marked as NA and hemagglutinin as HA. A highly pathogenic avian influenza A virus, A, is known to infect humans as well as its original avian hosts, albeit quite infrequently. [11]
Influenza A virus structure. The influenzavirus virion is pleomorphic; the viral envelope can occur in spherical and filamentous forms. In general, the virus's morphology is ellipsoidal with particles 100–120 nm in diameter, or filamentous with particles 80–100 nm in diameter and up to 20 μm long. [5]
Influenza A virus (Alphainfluenzavirus influenzae) [1] or IAV is the only species of the genus Alphainfluenzavirus of the virus family Orthomyxoviridae. [2] It is a pathogen with strains that infect birds and some mammals, as well as causing seasonal flu in humans. [3]
To unambiguously describe a specific isolate of virus, researchers use the Influenza virus nomenclature, [21] which describes, among other things, the subtype, year, and place of collection. Some examples include: [22] A/Rio de Janeiro/62434/2021 (H3N2). [22] The starting A indicates that the virus is an influenza A virus.
Structure of Influenza, showing neuraminidase marked as NA and hemagglutinin as HA Influenza virus replication, showing how in step 6 the neuraminidase and hemagglutinin proteins incorporated into the host cell's membrane are used to escape. Viral neuraminidase is a type of neuraminidase found on the surface of influenza viruses that enables the
Influenza viruses: You’re likely familiar with the seasonal flu, but in the last century there have also been four influenza pandemics: the infamous Spanish Flu pandemic in 1918, the H2N2 flu ...
Influenza A virus can infect a variety of animals as well as humans, and its natural reservoir (natural host) is birds, whereas influenza viruses B, C, and D do not have animal reservoirs. [4] [11] [8] Influenza C virus is not as easily isolated so less information is known of this type, but studies show that it occurs worldwide. [12]