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Rivastigmine, sold under the brand name Exelon among others, is an acetylcholinesterase inhibitor used for the treatment of dementia associated with Alzheimer's disease and with Parkinson's disease. [ 4 ] [ 6 ] [ 7 ] Rivastigmine can be administered orally or via a transdermal patch ; the latter form reduces the prevalence of side effects, [ 8 ...
[13] [14] After developing rivastigmine, her research focus turned to finding a preventative treatment for Alzheimer's. [15] Weinstock-Rosin won the 2014 Israel Prize for Medicine for her discovery of rivastigmine. [16] She is an emeritus professor at the Hebrew University's School of Pharmacy. [2]
When used in the central nervous system to alleviate neurological symptoms, such as rivastigmine in Alzheimer's disease, all cholinesterase inhibitors require doses to be increased gradually over several weeks, and this is usually referred to as the titration phase. Many other types of drug treatments may require a titration or stepping up phase.
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Paraoxon and rivastigmine are both acetylcholinesterase inhibitors and butyrylcholinesterase inhibitors. [14] [11] [7]In 2015, the United States Food and Drug Administration's Adverse Event Reporting System database compared rivastigmine to the other ChEI drugs donepezil and galantamine found that rivastigmine was associated with a higher frequency of reports of death as an adverse event.
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Depakote (valproic acid/sodium valproate) – an antiepileptic and mood stabilizer used to treat bipolar disorder, neuropathic pain and others; sometimes called an antimanic medication.
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