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A DNA polymerase is a member of a family of enzymes that catalyze the synthesis of DNA molecules from nucleoside triphosphates, the molecular precursors of DNA. These enzymes are essential for DNA replication and usually work in groups to create two identical DNA duplexes from a single original DNA duplex. During this process, DNA polymerase ...
All the functions of DNA depend on interactions with proteins. These protein interactions can be non-specific, or the protein can bind specifically to a single DNA sequence. Enzymes can also bind to DNA and of these, the polymerases that copy the DNA base sequence in transcription and DNA replication are particularly important.
The structure of the DNA double helix (type B-DNA). The atoms in the structure are colour-coded by element and the detailed structures of two base pairs are shown in the bottom right. DNA exists as a double-stranded structure, with both strands coiled together to form the characteristic double helix.
Many nucleases participate in DNA repair by recognizing damage sites and cleaving them from the surrounding DNA. These enzymes function independently or in complexes. Most nucleases involved in DNA repair are not sequence-specific. They recognize damage sites through deformation of double stranded DNA (dsDNA) secondary structure. [5]
DNA polymerase III synthesizes base pairs at a rate of around 1000 nucleotides per second. [3] DNA Pol III activity begins after strand separation at the origin of replication. Because DNA synthesis cannot start de novo, an RNA primer, complementary to part of the single-stranded DNA, is synthesized by primase (an RNA polymerase): [citation ...
There's also metabolic enzymes, which belong to the transferases category and help convert food into energy; or repair enzymes, that help fix damaged or mutated DNA. "Detoxification enzymes, like ...
The basic units of chromatin structure. Histone-modifying enzymes are enzymes involved in the modification of histone substrates after protein translation and affect cellular processes including gene expression. [1] [2] To safely store the eukaryotic genome, DNA is wrapped around four core histone proteins (H3, H4, H2A, H2B), which then join to ...
Although RNA enzymes were discovered before DNA enzymes, the latter have some distinct advantages. DNA is more cost-effective, and DNA can be made with longer sequence length and can be made with higher purity in solid-phase synthesis. [30] Several studies have shown the usage of DNAzymes to inhibit influenza A and B virus replication in host ...