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The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts.
The same Hox protein can act as a repressor at one gene and an activator at another. The ability of Hox proteins to bind DNA is conferred by a part of the protein referred to as the homeodomain. The homeodomain is a 60-amino-acid-long DNA-binding domain (encoded by its corresponding 180-base-pair DNA sequence, the homeobox
Homeobox genes encode homeodomain protein products that are transcription factors sharing a characteristic protein fold structure that binds DNA to regulate expression of target genes. [ 3 ] [ 4 ] [ 2 ] Homeodomain proteins regulate gene expression and cell differentiation during early embryonic development, thus mutations in homeobox genes can ...
Homeobox protein Hox-C6 is a protein that in humans is encoded by the HOXC6 gene. [ 5 ] [ 6 ] [ 7 ] Hox-C6 expression is highest in the fallopian tube and ovary. [ 8 ] HoxC6 has been highly expressed in many types of cancers including prostate, breast, and esophageal squamous cell cancer.
ShutterstockIt's no secret that protein is an essential nutrient for building muscle mass, supporting healthy weight management, and bolstering the immune system. But protein isn't vital only for ...
Fast food gets a bad rap for being unhealthy, but there are healthy fast food options at chains like McDonald’s, Pizza Hut, and Sonic. Dietitians explain.
The POU domain is a bipartite domain composed of two subunits separated by a non-conserved region of 15-55 aa. The N-terminal subunit is known as the POU-specific (POUs) domain (InterPro: IPR000327), while the C-terminal subunit is a homeobox domain (InterPro: IPR007103). 3D structures of complexes including both POU subdomains bound to DNA are available.
Here's how protein can help trim belly fat. Here's how protein can help trim belly fat. Skip to main content. 24/7 Help. For premium support please call: 800-290-4726 more ways to reach us ...