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The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts.
The same Hox protein can act as a repressor at one gene and an activator at another. The ability of Hox proteins to bind DNA is conferred by a part of the protein referred to as the homeodomain. The homeodomain is a 60-amino-acid-long DNA-binding domain (encoded by its corresponding 180-base-pair DNA sequence, the homeobox
Homeobox genes encode homeodomain protein products that are transcription factors sharing a characteristic protein fold structure that binds DNA to regulate expression of target genes. [ 3 ] [ 4 ] [ 2 ] Homeodomain proteins regulate gene expression and cell differentiation during early embryonic development, thus mutations in homeobox genes can ...
Serving size: 3 ounces (85 grams) Calories: 84 Protein: 20 grams Fat: 0 grams Shrimp is a low-fat protein source rich in omega-3 fatty acids and selenium, which are crucial for heart health and ...
Fast food gets a bad rap for being unhealthy, but there are healthy fast food options at chains like McDonald’s, Pizza Hut, and Sonic. Dietitians explain. ... Karin Evans, Ph.D., R.D., C.H.E.S ...
The POU domain is a bipartite domain composed of two subunits separated by a non-conserved region of 15-55 aa. The N-terminal subunit is known as the POU-specific (POUs) domain (InterPro: IPR000327), while the C-terminal subunit is a homeobox domain (InterPro: IPR007103). 3D structures of complexes including both POU subdomains bound to DNA are available.
engrailed is a homeodomain transcription factor [1] involved in many aspects of multicellular development. First known for its role in arthropod embryological development, working in consort with the Hox genes, engrailed has been found to be important in other areas of development.
Fat Joe revealed what has helped him keep his weight down and eat healthier: cutting carbs. “We just try to eat everything with the least carbs as possible,” Joe, 54, exclusively told Us ...