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Tolvaptan, sold under the brand name Samsca among others, is an aquaretic drug that functions as a selective, competitive vasopressin receptor 2 (V 2) antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.
Tolvaptan was studied in DILIsym®, a state of the art, multiscale computational model that uses non-clinical and clinical drug data to predict whether a drug could cause idiosyncratic liver toxicity. [16] DILIsym® replicated accurately the liver toxicity observed with tolvaptan in clinical studies. [17]
"abdominal pain, diarrhea, potentially carcinogenic, with others can potentiate cardiac glycosides and antiarrhythmic agents" [3] Chaparral: creosote bush, gobernadora, larreastat [4] Larrea tridentata, Larrea divaricata [4] Liver damage, [3] [4] [5] kidney problems, [4] Hypotension in cancer patients [3] Chinese herbal mixtures: Heavy metal ...
Fatty liver disease happens when fat builds up in your liver. This can cause damage, inflammation, and other complications. ... Liver cancer. High blood pressure. Type 2 diabetes.
"The data does not allow a definitive answer, and there also appears to be significant variation among people in their susceptibility to liver damage from green tea," Dr. Clarke points out.
The liver damage can consist of damage to liver cells, hepatic sinusoidal syndrome (obstruction of the veins in the liver), cholestasis (where bile does not flow from the liver to the intestine) and liver fibrosis. [127] [128] Nephrotoxicity (kidney damage) can be caused by tumor lysis syndrome and also due direct effects of drug clearance by ...
As for liver risks, Tejada says risks include liver toxicity, hepatitis, and liver failure, with toxicity believed to be dose-dependent and possibly due to excessive accumulation of catechins in ...