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To conduct organic synthesis without human involvement, researchers are adapting existing synthetic methods and techniques to create entirely automated synthetic processes using organic synthesis software. This type of synthesis is advantageous as synthetic automation can increase yield with continual "flowing" reactions.
Bioretrosynthesis is a technique for synthesizing organic chemicals from inexpensive precursors and evolved enzymes. [1] The technique builds on the retro-evolution hypothesis proposed in 1945 by geneticist Norman Horowitz. [2]
Biomimetic synthesis is an area of organic chemical synthesis that is specifically biologically inspired. The term encompasses both the testing of a "biogenetic hypothesis" (conjectured course of a biosynthesis in nature) through execution of a series of reactions designed to parallel the proposed biosynthesis, as well as programs of study where a synthetic reaction or reactions aimed at a ...
Total synthesis targets can also be organometallic or inorganic. [5] [6] While total synthesis aims for complete construction from simple starting materials, modifying or partially synthesizing these compounds is known as semisynthesis. Natural product synthesis serves as a critical tool across various scientific fields.
DNA‐templated organic synthesis (DTS) is a way to control the reactivity of synthetic molecules by using nature's molarity‐based approach. Historically, DTS was used as a model of prebiotic nucleic acid replication. Now however, it is capable of translating DNA sequences into complex small‐molecule and polymer products of multistep ...
For example, while synthetic biology may lead to more efficient production of medical treatments, it may also lead to synthesis or modification of harmful pathogens (e.g., smallpox). [213] The biohacking community remains a source of special concern, as the distributed and diffuse nature of open-source biotechnology makes it difficult to track ...
The split and pool synthesis (S&P synthesis) differs from traditional synthetic methods. The important novelty is the use of compound mixtures in the process. This is the reason of its unprecedentedly high productivity. Using the method one single chemist can make more compounds in a week than all chemists produced in the whole history of ...
Medicinal chemists use the techniques of chemical synthesis to insert new chemical groups into the biomedical compound and test the modifications for their biological effects. This method was refined to build mathematical relationships between the chemical structure and the biological activity, known as quantitative structure–activity ...