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This means, for example, that in the case of a cis-regulatory module regulated by two transcription factors, experimentally determined gene-regulation functions can not be described by the 16 possible Boolean functions of two variables. Non-Boolean extensions of the gene-regulatory logic have been proposed to correct for this issue.
[22] [23] Furthermore, alternative transcription initiation within the CDS may generate protein isoforms with varied functions in S. cerevisiae. [24] These examples from the model organism S. cerevisiae suggest that mRNA transcripts with alternative 5′ TLs may have a regulatory function in eukaryotes especially during events requiring ...
This is a list of cis-regulatory RNAs. These are RNA motifs which regulate nucleic acid regions on the same molecule, as opposed to trans -acting motifs which regulate a distal molecule. Some of these RNAs are broadly distributed while others are single RNA families.
Cis-regulatory DNA sequences that are located in DNA regions distant from the promoters of genes can have very large effects on gene expression, with some genes undergoing up to 100-fold increased expression due to such a cis-regulatory sequence. [36] These cis-regulatory sequences include enhancers, silencers, insulators and tethering elements ...
Cis-regulatory DNA sequences that are located in DNA regions distant from the promoters of genes can have very large effects on gene expression, with some genes undergoing up to 100-fold increased expression due to such a cis-regulatory sequence. [3] These cis-regulatory sequences include enhancers, silencers, insulators and tethering elements. [4]
An insulator is a type of cis-regulatory element known as a long-range regulatory element.Found in multicellular eukaryotes and working over distances from the promoter element of the target gene, an insulator is typically 300 bp to 2000 bp in length. [1]
This is a rendering of cis-acting replication element inspired by an image of common cre structure found in Coronavirus from a review paper by Sola et al., 2015 [1]. Cis-acting replication elements (cre) bring together the 5′ and 3′ ends during replication of positive-sense single-stranded RNA viruses (for example Picornavirus, Flavivirus, Coronavirus, Togaviruses, Hepatitis C virus) and ...
A locus control region (LCR) is a long-range cis-regulatory element that enhances expression of linked genes at distal chromatin sites. It functions in a copy number-dependent manner and is tissue-specific, as seen in the selective expression of β-globin genes in erythroid cells. [1]