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Sp100 nuclear antigen is an interferon stimulated antigen found in the cell nuclei of many human and higher animal cells. Autoantibodies directed against Sp100 are often found in patients with primary biliary cirrhosis. [1] Histologically Sp100 'dots' regions of the cell nucleus. Viral infection and mitogens affect the expression of the Sp100 ...
Anti-sp100 antibodies are found in association with primary biliary cirrhosis. [1] The autoimmune target of anti-sp100 is the sp100 nuclear antigen which was identified by its association with primary biliary cirrhosis . 20-30% of patients with primary biliary cirrhosis have sp100 Abs.
The RanBP2 gene encodes a very large RAN-binding protein that localizes to cytoplasmic filaments emanating from the nuclear pore complex. RanBP2/Nup358 is a giant scaffold and mosaic cyclophilin -related nucleoporin implicated in controlling selective processes of the Ran-GTPase cycle .
Nucleofection is a method to transfer substrates into mammalian cells so far considered difficult or even impossible to transfect. Examples for such substrates are nucleic acids, like the DNA of an isolated gene cloned into a plasmid, or small interfering RNA (siRNA) for knocking down expression of a specific endogenous gene.
DNA transposons, LTR retrotransposons, SINEs, and LINEs make up a majority of the human genome. Mobile genetic elements (MGEs), sometimes called selfish genetic elements, [1] are a type of genetic material that can move around within a genome, or that can be transferred from one species or replicon to another.
If it wasn’t clear before, it is now: President-elect Donald Trump plans to boost the cryptocurrency industry while continuing a broad antitrust crackdown on Big Tech giants such as Amazon, Meta ...
SP110 nuclear body protein is a protein that in humans is encoded by the SP110 gene. [4] [5] [6] The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein ...
Texas Lt. Gov. Dan Patrick said U.S.-owned border wall materials, which were available for sale, were pulled from an Arizona auction at the government's request. The Lonestar State had shown ...