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Parkinson's disease (PD), or simply Parkinson's, is a neurodegenerative disease primarily of the central nervous system, affecting both motor and non-motor systems. Symptoms typically develop gradually, with non-motor issues becoming more prevalent as the disease progresses.
Parkinson's disease patient showing a typical flexed walking posture in advanced stage. Signs and symptoms of Parkinson's disease are varied. Parkinson's disease affects movement, producing motor symptoms. [1] Non-motor symptoms, which include dysautonomia, cognitive and neurobehavioral problems, and sensory and sleep difficulties, are also ...
Parkinsonism is a clinical syndrome characterized by tremor, bradykinesia (slowed movements), rigidity, and postural instability. [ 1 ] [ 2 ] Both hypokinetic (bradykinesia and akinesia) as well as hyperkinetic (cogwheel rigidity and tremors at rest) features are displayed by Parkinsonism. [ 3 ]
Parkinson's disease dementia can only be definitively diagnosed after death with an autopsy of the brain. [6] The 2017 Fourth Consensus Report established diagnostic criteria for PDD and DLB. [ 9 ] The diagnostic criteria are the same for both conditions, except that PDD is distinguished from DLB by the time frame in which dementia symptoms ...
While many environmental factors may exacerbate Parkinson's disease, exercise is considered to be one of the main protective factors for neurodegenerative disorders, including Parkinson's disease. The types of exercise interventions that have been studied can be categorized as either aerobic or goal-based. [ 47 ]
Additional Parkinson-plus syndromes include Pick's disease and olivopontocerebellar atrophy. [7] The latter is characterized by ataxia and dysarthria, and may occur either as an inherited disorder or as a variant of multiple system atrophy. MSA is also characterized by autonomic failure, formerly known as Shy–Drager syndrome. [8]
Mervyn Peake (1911–1968; aged 57), English author and illustrator. [ 157 ] George Perles (1934–2020; aged 85), American football player, defensive coordinator for the Pittsburgh Steelers , head football coach at Michigan State University .
The history of Parkinson's disease expands from 1817, when British apothecary James Parkinson published An Essay on the Shaking Palsy, to modern times. Before Parkinson's descriptions, others had already described features of the disease that would bear his name , while the 20th century greatly improved knowledge of the disease and its ...
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