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The initiation of endochondral ossification starts by proliferation and condensation of mesenchymal cells in the area where the bone will eventually be formed. Subsequently, these mesenchymal progenitor cells differentiate into chondroblasts, which actively synthesize cartilage matrix components.
It is synonymous with bone tissue formation. [1] There are two processes resulting in the formation of normal, healthy bone tissue: [2] Intramembranous ossification is the direct laying down of bone into the primitive connective tissue , while endochondral ossification involves cartilage as a precursor.
The bones that form the base and facial regions of the skull develop through the process of endochondral ossification. In this process, mesenchyme accumulates and differentiates into hyaline cartilage, which forms a model of the future bone. The hyaline cartilage model is then gradually, over a period of many years, displaced by bone.
A schematic for long bone endochondral ossification: [4] Primary endochondral ossification begins with the formation of a chondrocyte template. Afterwards, chondrocytes undergo hypertrophy beginning from the mid-diaphysis, eventually extending to the epiphyseal poles, vasculature invades the forming bone transporting mesenchymal stromal cells ...
Endochondral ossification occurs in long bones and most other bones in the body; it involves the development of bone from cartilage. This process includes the development of a cartilage model, its growth and development, development of the primary and secondary ossification centers , and the formation of articular cartilage and the epiphyseal ...
Its lateral end is formed by intramembranous ossification while medially it is formed by endochondral ossification. It consists of a mass of cancellous bone surrounded by a compact bone shell. The cancellous bone forms via two ossification centres , one medial and one lateral, which fuse later on.
Tests of animal bones found nearby suggest that the climate was harsh — comparable to modern-day Siberia. That means humans were having success in an extreme climate some 45,000 years ago.
The skull roof bones, comprising the bones of the facial skeleton and the sides and roof of the neurocranium, are dermal bones formed by intramembranous ossification, though the temporal bones are formed by endochondral ossification. The endocranium, the bones supporting the brain (the occipital, sphenoid, and ethmoid) are largely formed by ...