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At the beginning of the test, the drug is added to the donor compartment, and the acceptor compartment is drug-free. After an incubation period which may include stirring, the sandwich is separated and the amount of drug is measured in each compartment. Mass balance allows calculation of drug that remains in the membrane.
The cm corresponds in the permeability equations to the thickness of the material whose permeability is being evaluated, the cm 3 STP cm −2 s −1 to the flux of gas through the material, and the cmHg to the pressure drop across the material. That is, it measures the rate of fluid flow passing through an area of material with a thickness ...
In physics and engineering, permeation (also called imbuing) is the penetration of a permeate (a fluid such as a liquid, gas, or vapor) through a solid.It is directly related to the concentration gradient of the permeate, a material's intrinsic permeability, and the materials' mass diffusivity. [1]
A practical unit for permeability is the darcy (d), or more commonly the millidarcy (md) (1 d ≈ 10 −12 m 2). The name honors the French Engineer Henry Darcy who first described the flow of water through sand filters for potable water supply. Permeability values for most materials commonly range typically from a fraction to several thousand ...
Staverman's reflection coefficient, σ, is a unitless constant that is specific to the permeability of a membrane to a given solute. [ 6 ] The Starling equation, written without σ , describes the flow of a solvent across a membrane that is impermeable to the solutes contained within the solution.
P is the permeability, an experimentally determined membrane "conductance" for a given gas at a given temperature, c 2 − c 1 is the difference in concentration of the gas across the membrane for the direction of flow (from c 1 to c 2). Fick's first law is also important in radiation transfer equations.
The membrane used in the process is a generally non-porous layer, so there will not be a severe leakage of gas through the membrane. The performance of the membrane depends on permeability and selectivity. Permeability is affected by the penetrant size. Larger gas molecules have a lower diffusion coefficient.
The permeability of a membrane is the rate of passive diffusion of molecules through the membrane. These molecules are known as permeant molecules. Permeability depends mainly on the electric charge and polarity of the molecule and to a lesser extent the molar mass of the molecule. Due to the cell membrane's hydrophobic nature, small ...