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PET studies with antihistamines have found that brain H 1 receptor occupancy of more than 50% is associated with a high prevalence of somnolence and cognitive decline, whereas brain H 1 receptor occupancy of less than 20% is considered to be non-sedative. [46] Hydroxyzine also acts as a functional inhibitor of acid sphingomyelinase. [47]
Carbinoxamine is an antihistamine and anticholinergic agent. It is used for hay fever, vasomotor rhinitis, mild urticaria, angioedema, dermatographism and allergic conjunctivitis. Carbinoxamine is a histamine antagonist, specifically an H1-antagonist. The maleic acid salt of the levorotatory isomer is sold as the prescription drug rotoxamine.
Chemist Warehouse Group (trading as Chemist Warehouse, My Chemist, My Beauty Spot) [3] is an Australian company operating a chain of retail pharmacies both locally and internationally. The company is one of Australia's largest pharmacy retailers with over 500 stores in Australia, [ 4 ] and employs over 20,000 staff. [ 5 ]
Many pharmacy chains in the United States are owned and operated by regional supermarket brands, or national big-box store brands such as Walmart. These pharmacies are located within their larger chain stores. The three largest free-standing pharmacy chains in the United States are Walgreens, CVS, and Rite Aid.
H 1-antihistamines work by binding to histamine H 1 receptors in mast cells, smooth muscle, and endothelium in the body as well as in the tuberomammillary nucleus in the brain. Antihistamines that target the histamine H 1-receptor are used to treat allergic reactions in the nose (e.g., itching, runny nose, and
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