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Mannose is a sugar with the formula HOCH 2 (CHOH) 4 CHO.It is one of the monomers of the aldohexose series of carbohydrates.It is a C-2 epimer of glucose.Mannose is important in human metabolism, especially in the glycosylation of certain proteins.
In enzymology, a mannose isomerase (EC 5.3.1.7) is an enzyme that catalyzes the chemical reaction D-mannose ⇌ {\displaystyle \rightleftharpoons } D-fructose Hence, this enzyme has one substrate , D-mannose , and one product , D-fructose .
Hydrolysis of terminal, non-reducing β-D-mannose residues in β-D-mannosides This gene encodes a member of the glycosyl hydrolase 2 family . The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N -linked glycoprotein oligosaccharide catabolism.
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It can be utilized in experiments that determine the effects of the presence or absence of mannose on specific molecules, such as recombinant proteins that are used in vaccine development. [ 5 ] Pathology
Since only GDP-L-gulose (the C5-epimer of GDP-D-mannose) was found in the reaction mixture, it was postulated that the enzyme performs the C5-epimerization prior to the C3-epimerization. However, GDP-D-altrose was recently found as a reaction product, which means that both reaction routes can occur: C5-prior-to-C3 and C3-prior-to-C5.
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The systematic name of this enzyme class is GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming). Other names in common use include guanosine 5'-diphosphate- D -mannose oxidoreductase , guanosine diphosphomannose oxidoreductase , guanosine diphosphomannose 4,6-dehydratase , GDP- D -mannose dehydratase , GDP- D -mannose 4,6 ...